Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers
نویسندگان
چکیده
منابع مشابه
Identification of Small Molecule Inhibitors of Pre-mRNA Splicing*
Eukaryotic pre-mRNA splicing is an essential step in gene expression for all genes that contain introns. In contrast to transcription and translation, few well characterized chemical inhibitors are available with which to dissect the splicing process, particularly in cells. Therefore, the identification of specific small molecules that either inhibit or modify pre-mRNA splicing would be valuabl...
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Alternative pre-messenger RNA splicing is an important mechanism for generating protein diversity and may explain in part how mammalian complexity arises from a surprisingly small complement of genes. Here, we describe "digital polony exon profiling,"a single molecule-based technology for studying complex alternative pre-messenger RNA splicing. This technology allows researchers to monitor the ...
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Since I started in the pre-mRNA splicing field about three decades ago, I will beginn my little historical recollection at a somewhat earlier time than when the RNA journal started. To keep this somehow organized, I will summarize in decades, starting with the 1980s. What were significant changes in the RNA field over the past few decades? All of that from a very personal perspective. My own re...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2017
ISSN: 2041-1723
DOI: 10.1038/s41467-017-01559-4